Publications

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PUBLICATIONS

Y.D. Livney’s Theses

1.  M.S.: Recovery of Proteins from Thermoquarg Whey by Microfiltration of Carboxymethyl Cellulose Complexes. (1995), Supervisor: Prof. Robert L. Bradley, Food Science, University of Wisconsin, Madison, WI, USA.

2.  Ph.D.: Mechanisms of Swelling and Contraction of Nonionic Hydrophilic Polymer Gels in Presence of Low Molecular Weight Co-Solutes. (2002), Supervisors: Prof. Uri Cogan & Prof. Shimon Mizrahi, Food Engineering and Biotechnology, Technion- Israel Institute of Technology, Haifa, Israel.

 

Refereed papers in professional journals

Published papers

  1. Y. D. Livney, D. P. Donhowe, and R. W. Hartel, Influence of Temperature on Crystallization of Lactose in Ice-cream, International Journal of Food Science and Technology 30 (1995) 311-320.
  2. Y. D. Livney, O. Ramon, E. Kesselman, U. Cogan, S. Mizrahi, and Y. Cohen, Swelling of Dextran Gel and Osmotic Pressure of Soluble Dextran in the Presence of Salts, Journal of Polymer Science, Part B. Polymer Physics 39 (2001) 2740-2750.
  3. Y. D. Livney, I. Portnaya, B. Faupin, O. Ramon, Y. Cohen, U. Cogan, and S. Mizrahi, Interactions between Inorganic Salts and Polyacrylamide in Aqueous Solutions and GelsJournal of Polymer Science: Part B: Polymer Physics 41 (2003) 508 –519.
  4. Y. D. Livney, I. Portnaya, B. Faupin, L. Fahoum, O. Ramon, Y. Cohen, S. Mizrahi, and U. Cogan, Interactions of Glucose and Polyacrylamide in Solutions and Gels, Journal of Polymer Science: Part B: Polymer Physics 41 (2003) 3053-3063.
  5. Y. D. Livney, E. Verespej, and D. G. Dalgleish, Steric Effects Governing Disulfide Bond Interchange during Thermal Aggregation in Solutions of β-Lactoglobulin B and α-lactalbuminJournal of Agricultural and Food Chemistry 51 (2003) 8098-8106.
  6. Y. D. Livney, and D. G. Dalgleish, Specificity of Disulfide Bond Formation during Thermal Aggregation in Solutions of β-Lactoglobulin B and k-Casein A , Journal of Agricultural and Food Chemistry 52 (2004) 5527-5532.
  7. Y. D. Livney, A. Schwan, and D. G. Dalgleish, A Study of β-Casein Tertiary Structure by Intramolecular Crosslinking and Mass SpectrometryJournal of Dairy Science 87 (2004) 3638-3647.
  8. I. Portnaya, U. Cogan, Y. D. Livney, O. Ramon, K. Shimoni, M. Rosenberg, and D. Danino, Micellization of Bovine β-Casein Studied by Isothermal Titration Microcalorimetry and Cryogenic-Transmission Electron Microscopy, Journal of Agricultural and Food Chemistry 54 (2006) 5555-5561.
  9. E. Semo, E. Kesselman, D. Danino, and Y. D. Livney, Casein Micelle as a Natural Nano-Capsular Vehicle for NutraceuticalsFood Hydrocolloids 21 (2007) 936-942.
  10. A. Shpigelman, I. Portnaya, O. Ramon, and Y. D. Livney, Saccharide-Structure Effects on Poly N-Isopropylacrylamide Phase Transition in Aqueous Media: Reflections on Protein StabilityJournal of Polymer Science: Part B: Polymer Physics 46 (2007) 2307-2318.
  11. P. Zimet, and Y. D. Livney, Beta-Lactoglobulin and its Nanocomplexes with Pectin as Vehicles for ω-3 Polyunsaturated Fatty Acids, Food Hydrocolloids 23 (2009) 1120–1126.
  12. I. Shechter, O. Ramon, Y. Paz, and Y. D. Livney, Microcalorimetric Study of the Effects of a Chaotropic Salt, KSCN, on the Lower Critical Solution Temperature (LCST) of Aqueous Poly(N-isopropylacrylamide) (PNIPA) Solutions, Macromolecules 43 (2010) 480–487.
  13. A. Shapira, Y. G. Assaraf, and Y. D. Livney, Beta-Casein Nanovehicles for Oral Delivery of Chemotherapeutic DrugsNanomedicine: Nanotechnology, Biology and Medicine 6 (2010) 119-126.
  14. R. I. Pinhassi, Y. G. Assaraf, S. Farber, M. Stark, D. Ickowicz, S. Drori, A. J. Domb, and Y. D. Livney, Arabinogalactan-Folic acid-Drug Conjugate for Targeted Delivery and Target-Activated Release of Anticancer Drugs to Folate Receptor-Overexpressing Cells, Biomacromolecules, 11 (2010) 294-303.
  15. A. Shpigelman, G. Israeli, and Y. D. Livney, Thermally-Induced Protein- Polyphenol Co-Assemblies: Beta lactoglobulin-Based complexes as Protective Nanovehicles for EGCG, Food Hydrocolloids 24 (2010) 735-743.
  16. A. Shapira, G. Markman, Y. G. Assaraf, and Y. D. Livney, Beta-Casein Based Nano-Vehicles for Oral Delivery of Chemotherapeutic Drugs: Drug-Protein Interactions and Mitoxantrone Loading Capacity, Nanomedicine: Nanotechnology, Biology and Medicine 6 (2010) 547-555.
  17. N. Ron, P. Zimet, J. Bargarum, and Y. D. Livney, Beta-Lactoglobulin – Polysaccharide Complexes as Nanovehicles for Hydrophobic Nutraceuticals in Non-Fat Foods and Clear Beverages, International Dairy Journal 20 (2010) 686-693.
  18. A. Shapira, D. Epstein, Y. G. Assaraf, and Y. D. Livney, Beta-casein Nanoparticles as an Oral Delivery System for Chemotherapeutic Drugs: Impact of Drug Structure and Properties on Co-assembly, Pharmaceutical Research 27 (2010) 2175–2186.
  19. A. Shpigelman, Y. Paz, O. Ramon, and Y. D. Livney, Isomeric Sugar Effects on Thermal Phase Transition of Aqueous PNIPA Solutions, Probed by ATR-FTIR Spectroscopy; Insights to Protein Protection by Sugars, Colloid and Polymer Science 289 (2011) 281-290.
  20. P. Zimet, D. Rosenberg, and Y. D. Livney, Re-assembled Casein Micelles and Casein Nanoparticles as Nano-Vehicles for ω-3 Polyunsaturated Fatty Acids, Food Hydrocolloids 25 (2011) 1270-1276.
  21. N. Manukovsky, A. Shpigelman, R. Edelman, and Y. D. Livney, Hydration-Mediated Effects of Saccharide Stereochemistryon Poly(N-isopropylacrylamide) Gel Swelling, Journal of Polymer Science: Part B: Polymer Physics 47 (2011) 523-530.
  22. A. Shapira, I. Davidson, N. Avni, Y. G. Assaraf, and Y. D. Livney
    β-Casein Nanoparticle-Based Oral Drug Delivery System for Potential Treatment of Gastric Carcinoma: Stability, Target-Activated Release and Cytotoxicity, European Journal of Pharmaceutics and Biopharmaceutics 80 (2) (2012), 298–305.
  23. G. Markman, and Y. D. Livney, Maillard-Reaction Based Nano-Capsules for Protection of Water-Insoluble Nutraceuticals in Clear Drinks, Food & Function (2012) 3, 262-270.
  24. A. Shpigelman, Y. Cohen, and Y. D. Livney, Thermally-Induced β-Lactoglobuline-EGCG Nanovehicles: Loading, Stability, Sensory and Digestive-Release Study, Food Hydrocolloids 29 (2012) 57-67.
  25. M. Haham, S. Ish-Shalom (equally contributing first authors), M. Hefetz-Kustanovich, M. Nodelman, and Y. D. Livney, Stability and Bioavailability of Vitamin D Nanoencapsulated in Casein Micelles, Food & Function (2012) 3, 737-744.
  26. A. Shpigelman, A. Zisapel, Y. Cohen, and Y. D. Livney, Mechanisms of Saccharide Protection Against Epigallocatechin-3-Gallate Deterioration in Aqueous Solutions, Food Chemistry 139 (2013) 1105–1112.
  27. G. Israeli-Lev, and Y. D. Livney, Self-assembly of Hydrophobin and its Co-assembly with Hydrophobic Nutraceuticals in Aqueous Solutions: Towards Application as Delivery Systems, Food Hydrocolloids 35 (2014) 28-35.
  28. A. Shpigelman, Y. Shoham, G. Israeli-Lev, and Y. D. Livney, β-Lactoglobulin-Naringenin Complexes: Nano-Vehicles for the Delivery of a Hydrophobic Nutraceutical, Food Hydrocolloids 40 (2014) 214-224.
  29. Y. Levinson, G. Israeli-Lev, and Y. D. LivneySoybean β-Conglycinin Nanoparticles for Delivery of Hydrophobic Nutraceuticals, Food Biophysics 9(4) (2014), 332-340.
  30. S. David, Y. Zagury (equally contributing first authors), and Y. D. Livney, Soy β-Conglycinin-Curcumin Nanocomplexes for Enrichment of Clear Beverages, Food Biophysics 10(2) (2015), 195-206.
  31. O. Setter, and Y. D. Livney, The Effect of Sugar Stereochemistry on Protein Self-Assembly: The Case of β-Casein Micellization in Different Aldohexose Solutions, Physical Chemistry-Chemical Physics (2015) 17, 3599.
  32. R. Edelman, I. Kusner, R. Kisiliak, S. Srebnik and Y. D. Livney, Sugar Stereochemistry Effects on Water Structure and on Protein Stability: The Templating Concept, Food Hydrocolloids 48 (2015) 27-37.
  33. S. David, and Y. D. Livney, Potato Protein Based Nanovehicles for Health Promoting Hydrophobic Bioactives in Clear Beverages, Food Hydrocolloids 57 (2016) 229-235.
  34. Y. Levinson, S. Ish-Shalom, E. Segal, and Y. D. Livney, Bioavailability, Rheology and Sensory Evaluation of Fat-free Yogurt Enriched with VD3 Encapsulated in Re-assembled Casein Micelles, Food & Function 7 (2016), 1477-1482.
  35. M. Bar Zeev, Y. G. Assaraf, and Y. D. Livney, β-Casein Nano-vehicles for Oral Delivery of Chemotherapeutic Combinations Overcoming P-glycoprotein-Mediated Multidrug Resistance in Human Gastric Cancer, Oncotarget, 7 (2016), No. 17, 23322- 23334.
  36. G. Israeli-Lev, M. Pitchkhadze, S. Nevo, L. Fahoum, E. Meyron-Holtz, and Y. D. Livney, Harnessing Proteins to Control Crystal Size and Morphology, for Improved Delivery Performance of Hydrophobic Bioactives, using Genistein as a Model, Food Hydrocolloids 63, (2017), 97–107.
  37. Y. D. Livney, E. Ruimy, A. M. Ye, X. Zhu, and H. Singh, A Milkfat Globule Membrane-Inspired Approach for Encapsulation of Emulsion Oil Droplets, Food Hydrocolloids (2016).

 

Reports

Bioavailability of vitamin D encapsulated in casein micelles, compared to its bioavailability in the milk-fat. MINISTRY OF HEALTH, CHIEF SCIENTIST OFFICE: Research Report (2011)

Student Theses (Link to graduate school website)

 

Published Review Papers

  1. Y. D. Livney, and R. L. Bradley, Jr., Factors Affecting Flavor of Whey as an Ingredient in Ice Cream and Other Frozen Desserts, Cultured Dairy Products Journal 29 (1994) 23-27.
  2. Y. D. Livney, M. Corredig, and D. G. Dalgleish, Influence of Thermal Processing on the Properties of Dairy Colloids, Current Opinion in Colloids and Interface Science 8 (2003) 359-364.
  3. (Invited Review:) Y. D. Livney, Milk Proteins as Vehicles for Bioactives, Current Opinion in Colloids and Surface Science 15 (2010) 73-83. This paper was ranked 2nd in the Top 25 Hottest Articles in Current Opinion in Colloids and Surface Science July to September 2010!
  4. A. Shapira, Y. D. Livney, H. J. Broxterman, and Y. G. Assaraf, Nanomedicine for Targeted Cancer Therapy: Towards the Overcoming of Drug Resistance, Drug Resistance Updates, 14(3) (2011), 150-163.
  5. (Invited Review:) Y. D. Livney, and Y. G. Assaraf, Rationally Designed Nanovehicles to Overcome Cancer Chemoresistance, Advanced drug delivery reviews, 65(13) (2013), 1716-1730.
  6. (Editorial:) Y. D. Livney, U. Kulozik, and R. Gebhardt, Delivery of Functionality in Complex Food Systems: Physically Inspired Approaches from Nanoscale to Microscale: 5th Symposium, Special Issue of Food Biophysics, 9(4) (2014), 301-303.
  7. (Invited Review:) Y. D. Livney, Nanostructured Delivery Systems in Food: Latest Developments and Potential Future Directions, Current Opinion in Food Science 3 (2015), 125-135.

 

Published Book Chapters

  1. (Invited Review:) Y. D. Livney, Complexes and conjugates of biopolymers for delivery of bioactive ingredients via food, in: N. Garti (Ed.), Delivery and Controlled Release of Bioactives in Foods and Nutraceuticals, Woodhead Publishing Ltd. Abington, Cambridge, England 2008.
  2. (Invited Review:) Y. D. Livney, Polyelectrolytes: Properties, in: Savinell R., Ota K., Kreysa G. (Ed.) Encyclopedia of Applied Electrochemistry, Springer-Verlag Berlin Heidelberg.
    DOI: 10.1007/SpringerReference_30347
  3. (Invited Review:) Y. D. Livney, Biopolymeric amphiphiles and their assemblies as functional food ingredients and nutraceutical delivery systems, in: N. Garti, D.J. McClements (Eds.), Encapsulation Technologies and Delivery Systems for Food Ingredients and Nutraceuticals, Woodhead Publishing Ltd. Abington, Cambridge, England 2012.
  4. (Invited Review): Y. D. Livney, Nanoencapsulation technologies, in: Y. H. Roos and Y. D. Livney (Eds), Engineering Foods for Bioactives Stability and Delivery, Food Engineering Series, Gustavo V. Barbosa-Cánovas (Series Ed.), Springer.

 

Book Editing

  1. Engineering of Foods for Stabilization and Delivery of Bioactives, Y. H. Roos, and Y. D. Livney, Food Engineering Series, Gustavo V. Barbosa-Cánovas (Series Ed.), Springer.

 

Refereed Papers in Conference Proceedings

  1. Y. D. Livney, E. Semo, D. Danino, and E. Kesselman, Nanoencapsulation of Hydrophobic Nutraceutical Substances within Casein Micelles, XIVth International Workshop on Bioencapsulation, Lausanne, Switzerland, Oct. 6-7, 2006.
  2. Y. D. Livney, and N. Ron, Beta-Lactoglobulin (β-Lg) – Polysaccharide Complexes as Nanovehicles for Hydrophobic Nutraceuticals, XVth International Workshop on Bioencapsulation, Vienna, Austria, Sept. 6-8, 2007.
  3. Y. D. Livney, A. Shapira, and Y. G. Assaraf, Beta-Casein Micelles as Nano-Delivery Vehicles for Chemotherapeutic Drugs, XVIth International Workshop on Bioencapsulation, Dublin, Ireland, Sept. 4-6, 2008.
  4. Y. D. Livney, R. Edelman, I. Kusner, R. Kisiliak, and S. Srebnik, Water-Structure Effect of Sugar Stereochemistry, and its Impact on Protein Thermal Stability, Frontiers in Water Biophysics, Trieste, Italy, May 23-26, 2010.
  5. G. Markman, and Y. D. Livney,  Maillard-Reaction Based Nano-Capsules for Protection of Water-Insoluble Nutraceuticals in Clear Drinks. International Congress on Engineering and Food (ICEF11), Athens, Greece, May 22-26, 2011.
  6. A. Shapira, I. Davidson, N. Oron, Y. G. Assaraf, and Y. D. Livney, Beta Casein Nanovehicles for Targeted Oral Drug Delivery – Towards Treatment of Gastric Cancer, World Journal of Engineering, Vol. 8, Suppl. 1, 2011, ICCE-19 Shanghai.

 

Patents Granted

  1. Y. D. Livney, and D. G. Dalgleish, Casein micelle as a natural nano-capsular vehicle for nutraceuticals. European patent (EP 2007212 B1). Still pending: Provisional U.S. patent application (20.4.2006), and PCT 20-4-2007, National patent application (20.10.08).
  2. D. Danino, Y. D. Livney, O. Ramon, I. Portnaya, and U. Cogan, Beta-casein assemblies for enrichment of food and beverages and methods of preparation thereof. US Patent (US 8865222 B2).
  3. Y. D. Livney, β-Lactoglobulin-polysaccharide nanoparticles encapsulating hydrophobic biologically active compounds. US patent (US 8791064 B2); WO 2009130704 A1.
  4. Y. D. Livney, and A. Shpigelman, Denatured lactoglobulin and polyphenol coassemblies. US patent (US 9005664 B2).

Patents Pending

  1. Y. D. Livney, Y. G. Assaraf, A. Shapira, Nanoencapsulation of Chemotherapeutic and other Drugs in Beta- Casein Micelles (provisional US Patent application 29.2.2008) (currently after PCT application)
  2. Y. D. Livney Protein-polysaccharide conjugates and use for encapsulating nutraceuticals for clear beverage applications (provisional patent application 61/447773, 1.3.2011; US patent application number 13410001 1.3.2012).
  3. Y. D. Livney (Plant) protein nanoparticles. (provisional patent application submitted Sept 17.2013)
  4. Y. D. Livney (Polysaccharide) nanoparticles. (provisional patent application submitted 12.12.2013)